Nature

The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy

The EGF receptor (EGFR) has been extensively studied in tumor biology and recently a role in cardiovascular pathophysiology was suggested. The mineralocorticoid receptor (MR) is an important effector ...
BioWorld

T-type calcium channel inhibitor KTt‑45 demonstrates anticancer activity in vitro

T-type calcium channel inhibitor KTt‑45 demonstrates anticancer activity in vitro Jan. 3, 2024 ...
ascopubs.org

Sequential therapy with the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas: An Adult Brain Tumor Consortium ...

Phase II trial of triple-receptor tyrosine kinase receptor inhibitor nintedanib (BIBF 1120) in recurrent high-grade gliomas. This is an ASCO Meeting Abstract from the 2013 ASCO Annual Meeting I. This ...
Phys.org

Expanded role for calcium channels in T-cells

A subunit of voltage-gated calcium channels was found to have a functional role in T-cells, according to a Northwestern Medicine study published in Nature Communications. The findings add to a growing ...
Medical Xpress

Calcium channel blockers may improve chemotherapy response

Calcium channel blockers may improve treatment for pancreatic cancer patients receiving gemcitabine-based chemotherapy, according to recent findings published in the Proceedings of the National ...