DSBs are more likely to occur in some genomic regions than others. Elucidating mechanisms shaping the DSB “landscape” requires identifying the biochemical factors involved, understanding how they ...

A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation ...

Meiotic crossover formation between homologous chromosomes (homologues) entails DNA double-strand break (DSB) formation, homology search using DSB ends, and synaptonemal-complex formation coupled with ...

Researchers have identified a novel Heat Shock Factor (HSF), designated as HSF5, which plays a crucial role in the completion of meiosis and the activation of genes essential for sperm formation. This ...

During meiotic prophase, chromosome arrangement and oscillation promote the pairing of homologous chromosomes for meiotic recombination. This dramatic movement involves clustering of telomeres at the ...

Meiosis is the two-step series of cell divisions that make sexual reproduction and genetic diversity possible. Researchers have now dived into the process of meiosis in specific plant species and ...

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings. Meiotic ...

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings. Meiotic ...

The mystery of how meiotic arrest is maintained in mouse oocytes is revealed this week in Science by Lisa M. Mehlmann and colleagues at the University of Connecticut Health Center. The team reports ...

Deletion of hsf5 in mice results in the impaired development of testis (left), and the absence of spermatids and spermatozoa (right), which leads to the failure of sperm formation. Kumamoto University ...